Laodike I (Greek: Λαοδίκη) was the first queen consort of King Antiochos II Theos of Syria and the mother of King Seleukos II Kallinikos of Syria, Antiochos Hierax of Syria, Princess Apama of Syria, Queen (consort) Stratonike of Cappadocia, and Queen (consort) Laodike of Pontus. Laodike I was a daughter of Achaeos, the son of King Seleukos I Nikator of Syria.
Prophecy granted to Daniel
During the reign of King Cyprus of Persia, an angel told Daniel about things to come. The angel told Daniel of a daughter of the king the South being granted to the king of the North in a peace arrangement. The arrangement would not last, however. The new queen consort, her attendants, her father, and her supporter would be undone. Yet a portion of her family would arise and invade and defeat the North and carry away the North's idols, images, gold, and silver. The king of the South would refrain from further campaigns against the North for some time, but the king of the North would invade the South and fail.
Egypt is believed in be the kingdom of the South, and Syria is believed to be the kingdom of the North. Laodike's rival Berenike Phernophoros is believed to the the "daughter of the king of the South" mentioned in the prophecy.
After some years the Syrian king of the North and the Egyptian king of the South will make an alliance; the daughter (Berenice) of the king of the South will come to the king of the North to make an equitable and peaceful agreement (marriage); but she will not retain the power of her position, nor will he retain his power. She will be handed over with her attendants and her father as well as he who supported her in those times. But out of a branch of her [familial] roots will one (her brother, Ptolemy III Euergetes I) arise in his place, and he will come against the [Syrian] army and enter the fortress of the king of the North, and he will deal with them and will prevail. Also he will carry off to Egypt their [Syrian] gods with their cast images and their precious and costly treasure of silver and of gold, and he will refrain from waging war against the king of the North for some years. And the king of the North will come into the realm of the king of the South, but he will retreat to his own country [badly defeated].— Daniel 11:6–11:9 (AMP)
Laodike married her first cousin Antiochos II Theos of Syria, and they had several children together.
King Antiochos II fought against King Ptolemaios II Philadelphos of Egypt in the Second Syrian War. The two rulers eventually reached an accord: Antiochos II would divorce Laodike I, marry Ptolemaios II's daughter Berenike, and receive a large dowry, and any offspring born out of union between Berenike and Antiochos would displace Laodike's offspring in the order of succession.
Thus, Antiochos II divorced Laodike and married Berenike. Berenike and Antiochos II conceived a son, who they named Antiochos.
Laodike was not pleased with this new arrangement and intrigued against Antiochos and Berenike. When Ptolemaios II died, Antiochos II went to live with Laodike. Antiochos II died (some believe that Laodike poisoned him), and Laodike claimed that Antiochos II named Laodike's son Seleukos II Kallinikos his heir.
Berenike disputed this, claimed that her infant son Antiochos was the rightful heir to the throne, and request aid from her brother, King Ptolemaios III Euergetes of Egypt. However, Laodike's partisans assassinated Berenice and Antiochos before Ptolemaios III could arrived. Ptolemaios III then made war (the Third Syrian War) on Syria in retaliation.
Meanwhile, Laodike had her other son, Antiochos Hierax, seated in Sardis and named as Syria's co-ruler. With his mother's support, Antiochos Hierax rebelled against his brother Seleukos II and tried to create an independent kingdom for himself in Anatolia.
Ptolemaios III defeated Seleukos II and occupied and looted Antioch. He also captured Laodike and had her executed. Thus, the things foretold to Daniel came to past: Berenice was killed and Egypt defeated Syria in this round of combat.